Mumbai: Pharmaceuticals major Glenmark Pharmaceuticals on Tuesday said that it has initiated Phase 3 clinical trials in India on Antiviral tablet Favipiravir. The company had received approval from India’s drug regulator Drug Control General of India (DGCI) for the clinical trial of the drug.
Favipiravir is a generic version of Avigan® of Fujifilm Toyama Chemical Co. Ltd., Japan, a subsidiary of Fujifilm Corporation. Clinical trials have commenced and over 10 leading government & private hospitals in India are being enrolled for the study. Glenmark estimates study completion by July/August 2020.
Glenmark was the first pharmaceutical company in India to be given an approval by the regulatorto start the trial on COVID-19 patients in India. As per the approved clinical trial protocol, 150 subjects with mild to moderate COVID-19 will be randomized in the study in a 1:1 ratio to Favipiravir with standard supportive care or standalone standard supportive care. Treatment duration is a maximum of 14 days and the total study duration will be a maximum of 28 days from randomization.
“Glenmark has successfully developed the API and the formulations for the product through its inhouse R&D team. Favipiravir has demonstrated activity against influenza viruses and has been approved in Japan for the treatment of novel influenza virus infections. The molecule if commercialized, will be marketed under the brand name ‘FabiFlu®’ in India” the company said.
“Several health and medical experts, both in and outside of Glenmark are eager to see the effect that Favipiravir has on COVID-19 cases. We believe the study results will be significant as there is currently no effective treatment for the virus.” She added, “The data we get from these trials will point us in a clearer direction with regard to COVID-19 treatment and management” said Dr. Monika Tandon, Vice President & Head, Clinical Development, Global Specialty/Branded Portfolio, Glenmark Pharmaceuticals Ltd.